BDBM1116 (4R,5R,6R)-1,6-dibenzyl-5-hydroxy-4-(2-phenylethyl)-1,3-diazinan-2-one::(4R,5S,6R)-Tetrahydro-1,6-bis-(phenylmethyl)-5-hydroxy-4-(2-phenylethyl)-2(1H)-pyrimidinone::Tetrahydropyrimidinone deriv. 36

SMILES O[C@@H]1[C@@H](CCc2ccccc2)NC(=O)N(Cc2ccccc2)[C@@H]1Cc1ccccc1

InChI Key InChIKey=OVTFTTYZDSKPMS-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 1116   

TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University of Florida

Curated by ChEMBL
LigandPNGBDBM1116((4R,5S,6R)-Tetrahydro-1,6-bis-(phenylmethyl)-5-hyd...)
Affinity DataKi:  66nMAssay Description:Inhibitory activity of compound against HIV-1 aspartyl protease.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University of Florida

Curated by ChEMBL
LigandPNGBDBM1116((4R,5S,6R)-Tetrahydro-1,6-bis-(phenylmethyl)-5-hyd...)
Affinity DataKi:  66nMAssay Description:Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Dupont Pharmaceuticals

LigandPNGBDBM1116((4R,5S,6R)-Tetrahydro-1,6-bis-(phenylmethyl)-5-hyd...)
Affinity DataKi:  66nMAssay Description:Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University of Florida

Curated by ChEMBL
LigandPNGBDBM1116((4R,5S,6R)-Tetrahydro-1,6-bis-(phenylmethyl)-5-hyd...)
Affinity DataKi:  66nMAssay Description:Inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University of Florida

Curated by ChEMBL
LigandPNGBDBM1116((4R,5S,6R)-Tetrahydro-1,6-bis-(phenylmethyl)-5-hyd...)
Affinity DataKi:  66nMAssay Description:Compound was tested for the inhibitory activity against HIV-proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article