BDBM11113 6-{[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)ethyl]amino}pyridine-3-carbonitrile::BMCL15687 Compound 2::CHEMBL77538::NVP-DPP728::cyano-(S)-pyrrolidine deriv. 1::cyanopyrrolidine derivative 2
SMILES O=C(CNCCNc1ccc(cn1)C#N)N1CCC[C@H]1C#N
InChI Key InChIKey=VFFZWMWTUSXDCB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 32 hits for monomerid = 11113
Affinity DataIC50: 1.90E+5nMAssay Description:In vitro inhibitory activity against Post-proline cleaving enzyme (PPCE) obtained from human erythrocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of DPP-4 in human Epithelial cellMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of DPP4 in human plasma by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.20nMAssay Description:Inhibition of human DPP4 expressed in baculovirus expression system using Gly-Pro-AMC substrate incubated or 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of DPP4 in human plasma by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of human DPP4 expressed in baculovirus systemMore data for this Ligand-Target Pair
Affinity DataIC50: 4.57E+3nMAssay Description:Inhibitory concentration against Dipeptidylpeptidase 8More data for this Ligand-Target Pair
Affinity DataIC50: 2.65E+4nMAssay Description:Inhibitory concentration against DPP-II [Quiescent cell proline dipeptidase] or DPP-VIIMore data for this Ligand-Target Pair
Affinity DataIC50: 53nMAssay Description:Inhibitory concentration against Dipeptidylpeptidase IV [DPP-IV]More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibitory concentration against human dipeptidylpeptidase IVMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibitory concentration against rat dipeptidylpeptidase IVMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibitory concentration against dipeptidylpeptidase IVMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibitory activity against dipeptidylpeptidase IV.More data for this Ligand-Target Pair
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibitory activity against quiescent cell prolyl peptidase (QPP).More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of human dipeptidyl peptidase IV (DPP IV) obtained from human colonic carcinoma cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+5nMAssay Description:In vitro inhibitory activity against Dipeptidyl peptidase II (DPP II) obtained form bovine kidney homogenateMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibitory activity against Dipeptidyl peptidase IV (DPP IV) obtained from rat plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibitory activity against Dipeptidyl peptidase IV (DPP IV) obtained from human plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:In vitro inhibitory activity against Dipeptidyl peptidase IV (DPP-IV) extracted from Caco-2 cells.More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+5nMAssay Description:In vitro inhibitory activity against Dipeptidylpeptidase II (DPP-II) extracted from bovine kidney homogenateMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:In vitro inhibitory activity against Dipeptidyl peptidase IV (DPP-IV) extracted from rat plasma.More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:In vitro inhibitory activity against Dipeptidyl peptidase IV (DPP-IV) extracted from human plasma.More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.65E+4nMAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
Affinity DataIC50: 4.57E+3nMAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
Affinity DataIC50: 53nMpH: 8.0 T: 2°CAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
Affinity DataIC50: 2.65E+4nMAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
Affinity DataIC50: 53nMAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
Affinity DataIC50: 4.57E+3nMpH: 8.0 T: 2°CAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
Affinity DataKi: 11nM IC50: 15nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
Affinity DataKi: 27nM ΔG°: -10.3kcal/molepH: 7.4 T: 2°CAssay Description:The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...More data for this Ligand-Target Pair