BDBM110191 3-(2,4-Dihydroxyphenyl)-1-(thiophen-2-yl)propenone (13)

SMILES Oc1ccc(\C=C\C(=O)c2cccs2)c(O)c1

InChI Key InChIKey=HFJFEYAKDAKSFT-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 110191   

TargetCalpain-1 catalytic subunit(Human)
Ewha Womans University

LigandPNGBDBM110191(3-(2,4-Dihydroxyphenyl)-1-(thiophen-2-yl)propenone...)
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:Inhibition of µ-calpain was assayed in the reaction buffer (50 mM Tris-HCl, 50 mM NaCl, 1 mM EDTA, 1 mM EGTA and 5 mM β-mercaptoethanol, pH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2014
Entry Details Article
PubMed
TargetCalpain-2 catalytic subunit(Human)
Ewha Womans University

LigandPNGBDBM110191(3-(2,4-Dihydroxyphenyl)-1-(thiophen-2-yl)propenone...)
Affinity DataIC50: 6.02E+4nMpH: 7.5 T: 2°CAssay Description:Inhibition of m-calpain was assayed in the reaction buffer (50 mM Tris-HCl, 100 mM NaCl, 5 mM β-mercaptoethanol, and 1 mM EDTA, pH 7.5) with 50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2014
Entry Details Article
PubMed
TargetCathepsin B(Human)
Ewha Womans University

LigandPNGBDBM110191(3-(2,4-Dihydroxyphenyl)-1-(thiophen-2-yl)propenone...)
Affinity DataIC50: 1.15E+4nMpH: 5.5 T: 2°CAssay Description:Inhibition of cathepsin B was assayed in reaction buffer (50 mM NaOAc-HCl, 2 mM dithiothreitol, 2 mM EDTA, pH 5.5) containing 20 µM substrate an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2014
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Ewha Womans University

LigandPNGBDBM110191(3-(2,4-Dihydroxyphenyl)-1-(thiophen-2-yl)propenone...)
Affinity DataIC50: 2.80E+3nMpH: 5.5 T: 2°CAssay Description:Inhibition of cathepsin L was assayed in reaction buffer (0.1M NaOAc-HCl, 1 mM EDTA, 0.1% β-mercaptoethanol, pH 5.5) containing 20 µM subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2014
Entry Details Article
PubMed
TargetPolyphenol oxidase 2(White button mushroom)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM110191(3-(2,4-Dihydroxyphenyl)-1-(thiophen-2-yl)propenone...)
Affinity DataIC50: 0.0130nMAssay Description:Inhibition of mushroom tyrosinase using L-tyrosine as substrate assessed as diphenolase activity incubated for 20 mins by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPolyphenol oxidase 2(White button mushroom)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM110191(3-(2,4-Dihydroxyphenyl)-1-(thiophen-2-yl)propenone...)
Affinity DataIC50: 0.930nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as monophenolase activity incubated for 20 mins by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed