BDBM10955 (2S,6R)-3-methyl-8-oxa-3-azatricyclo[7.4.0.0^{2,6}]trideca-1(13),9,11-trien-10-yl N-heptylcarbamate hydrochloride::(3aR,9bS)-1-methyl-1,2,3,3a,4,9b-hexahydrochromeno[4,3-b]pyrrol-6-yl heptylcarbamate hydrochloride::Conformationally Restricted Rivastigmine Analogue 7

SMILES [H][C@@]12CCN(C)[C@]1([H])c1cccc(OC(=O)NCCCCCCC)c1OC2

InChI Key InChIKey=LCLQRXYSCAZUJT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 10955   

TargetCholinesterase(Human)
University of Bologna

LigandPNGBDBM10955((2S,6R)-3-methyl-8-oxa-3-azatricyclo[7.4.0.0^{2,6}...)
Affinity DataIC50: 1.26nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bologna

LigandPNGBDBM10955((2S,6R)-3-methyl-8-oxa-3-azatricyclo[7.4.0.0^{2,6}...)
Affinity DataIC50: 20.3nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2006
Entry Details Article
PubMed