BDBM108464 US8604016, 21::US9938267, Cmpd ID 21

SMILES O=C(Cc1ccccc1)Nc1nnc(CCCCc2nnc(NC(=O)Cc3ccccc3)s2)s1

InChI Key InChIKey=AMZWCCRFPBPFAY-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 108464   

TargetGlutaminase kidney isoform, mitochondrial(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM108464(US8604016, 21 | US9938267, Cmpd ID 21)
Affinity DataIC50: 160nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM108464(US8604016, 21 | US9938267, Cmpd ID 21)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human kidney type glutaminase (124 to 669 residues) using L-[3H]-glutamine as substrate after 45 mins by topcount methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details Article
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM108464(US8604016, 21 | US9938267, Cmpd ID 21)
Affinity DataIC50: 160nMAssay Description:No preinc (Column 4).More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM108464(US8604016, 21 | US9938267, Cmpd ID 21)
Affinity DataIC50: 160nMAssay Description:Inhibition of GAC (unknown origin) assessed as NADH formation using 10 mM glutamine as substrate preincubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM108464(US8604016, 21 | US9938267, Cmpd ID 21)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of human KGA preincubated for 15 to 30 mins followed by substrate addition and measured after 3 to 4 hrs by GDH-EZMTT reagent-based GDH co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM108464(US8604016, 21 | US9938267, Cmpd ID 21)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human recombinant GAC (72 to 598 residues) expressed in Escherichia coli BL21(DE3) after 10 mins by GluO-horseradish peroxidase coupled...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetGlutaminase liver isoform, mitochondrial(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM108464(US8604016, 21 | US9938267, Cmpd ID 21)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of GLS2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM108464(US8604016, 21 | US9938267, Cmpd ID 21)
Affinity DataIC50: 51nMAssay Description:Inhibition of recombinant 6His-tagged GLS1 KGA isoform (unknown origin) (63 to 669 residues) expressed in Escherichia coli using glutamine as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM108464(US8604016, 21 | US9938267, Cmpd ID 21)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of GAC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM108464(US8604016, 21 | US9938267, Cmpd ID 21)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GLS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed