BDBM108424 US8604206, (3R,4R,5S)-5(2-hydroxypropan-2-yl)piperidine-3,4-diol

SMILES CC(C)(O)[C@H]1CNC[C@@H](O)[C@@H]1O

InChI Key InChIKey=PVGDVTWSNAIFDH-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 108424   

TargetLysosomal acid glucosylceramidase(Human)
Amicus Therapeutics

US Patent
LigandPNGBDBM108424(US8604206, (3R,4R,5S)-5(2-hydroxypropan-2-yl)piper...)
Affinity DataKi:  15nM IC50: 29nMpH: 7.0Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
Go to US Patent

TargetLysosomal acid glucosylceramidase(Human)
Amicus Therapeutics

US Patent
LigandPNGBDBM108424(US8604206, (3R,4R,5S)-5(2-hydroxypropan-2-yl)piper...)
Affinity DataKi:  97nM IC50: 234nMpH: 5.2Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
Go to US Patent