BDBM108418 US8604206, 13::US8604206, 14

SMILES CC(F)[C@H]1CNC[C@@H](O)[C@@H]1O

InChI Key InChIKey=ADGVYUWMIQUOME-UHFFFAOYSA-N

Data  4 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 108418   

TargetLysosomal acid glucosylceramidase(Human)
Amicus Therapeutics

US Patent
LigandPNGBDBM108418(US8604206, 14 | US8604206, 13)
Affinity DataKi:  0.900nM IC50: 17.1nMpH: 7.0Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
Go to US Patent

TargetLysosomal acid glucosylceramidase(Human)
Amicus Therapeutics

US Patent
LigandPNGBDBM108418(US8604206, 14 | US8604206, 13)
Affinity DataKi:  4nM IC50: 7nMpH: 7.0Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
Go to US Patent

TargetLysosomal acid glucosylceramidase(Human)
Amicus Therapeutics

US Patent
LigandPNGBDBM108418(US8604206, 14 | US8604206, 13)
Affinity DataKi:  16nM IC50: 38nMpH: 5.2Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
Go to US Patent

TargetLysosomal acid glucosylceramidase(Human)
Amicus Therapeutics

US Patent
LigandPNGBDBM108418(US8604206, 14 | US8604206, 13)
Affinity DataKi:  49.8nM IC50: 94.6nMpH: 5.2Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
Go to US Patent