BDBM108083 3-(4-nitrobenzylidene)indolin-2-one (Compound 24)

SMILES [O-][N+](=O)c1ccc(\C=C2/C(=O)Nc3ccccc23)cc1

InChI Key InChIKey=WPZSQSSOBHCYOZ-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 108083   

TargetSecreted chorismate mutase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology

LigandPNGBDBM108083(3-(4-nitrobenzylidene)indolin-2-one (Compound 24))
Affinity DataIC50: 1.01E+3nMT: 2°CAssay Description:The reaction was initiated by the addition of 150pmoles of enzyme to a mixture of inhibitor (40µM, 20 µM, 10 µM, 5 µM, 1 µM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2014
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM108083(3-(4-nitrobenzylidene)indolin-2-one (Compound 24))
Affinity DataKi:  325nMAssay Description:Displacement of Thio-T from amyloid beta (1 to 42) (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM108083(3-(4-nitrobenzylidene)indolin-2-one (Compound 24))
Affinity DataKi:  347nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetMicrotubule-associated protein tau(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM108083(3-(4-nitrobenzylidene)indolin-2-one (Compound 24))
Affinity DataKi:  363nMAssay Description:Displacement of Thio-T from human recombinant tau (243 to 375) expressed in Escherichia coli BL21(DE3)RIL after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed