BDBM107712 US8598210, Table XV, 18::US8722895, 18: {[5-(3-Cyano-phenyl)-3-hydroxy-pyridine-2- carbonyl]-amino}-acetic acid methyl ester

SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)[N+]#[C-]

InChI Key InChIKey=UAWDTSDYMRFDAE-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 107712   

TargetEgl nine homolog 1(Human)
Akebia Therapeutics

US Patent
LigandPNGBDBM107712(US8722895, 18: {[5-(3-Cyano-phenyl)-3-hydroxy-pyri...)
Affinity DataIC50: 5.10E+3nMAssay Description:The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2014
Entry Details
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TargetVascular endothelial growth factor A(Human)
Akebia Therapeutics

US Patent
LigandPNGBDBM107712(US8722895, 18: {[5-(3-Cyano-phenyl)-3-hydroxy-pyri...)
Affinity DataEC50: >1.00E+5nMAssay Description:HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2014
Entry Details
Go to US Patent

TargetEgl nine homolog 1(Human)
Akebia Therapeutics

US Patent
LigandPNGBDBM107712(US8722895, 18: {[5-(3-Cyano-phenyl)-3-hydroxy-pyri...)
Affinity DataIC50: 5.10E+3nMT: 2°CAssay Description:The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2014
Entry Details
Go to US Patent