BDBM107598 US8575157, 45

SMILES C[C@H](N1CC[C@@](CCCO)(OC1=O)c1ccccc1)c1ccc(cc1)-c1cc[nH]c(=O)c1

InChI Key InChIKey=UWDFOMGWYKIOAS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 107598   

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM107598(US8575157, 45)
Affinity DataIC50: 1.58nMAssay Description:The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2014
Entry Details
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Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM107598(US8575157, 45)
Affinity DataIC50: 11.8nMAssay Description:Inhibition assay using 11β-HSD1 in the presence of 50% human plasma. More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2014
Entry Details
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TargetCytochrome P450 2C9(Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM107598(US8575157, 45)
Affinity DataIC50: 1.52E+4nMAssay Description:The inhibition of recombinant CYP2C9 by compounds of the invention was measured using a commercial kit from Invitrogen (cat #2859).More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2014
Entry Details
Go to US Patent