BDBM107482 US8575157, 190::US8592410, Comparator 2::US8598163, 60
SMILES OCCC1(CCN(C(=O)O1)c1cccc(n1)-c1ccc(F)cc1F)c1ccccc1F
InChI Key InChIKey=ZZNUHDXNMHQWAV-UHFFFAOYSA-N
Data 7 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 107482
Affinity DataIC50: 1.80nMAssay Description:The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...More data for this Ligand-Target Pair
Affinity DataIC50: 14.2nMAssay Description:The inhibition assay using 11β-HSD1.More data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:The inhibition of recombinant CYP2C9 by compounds of the invention was measured using a commercial kit from Invitrogen (cat #2859).More data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...More data for this Ligand-Target Pair
Affinity DataIC50: 14.2nMAssay Description:Inhibition assay using 11β-HSD1 in the presence of 50% human plasma. More data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMpH: 7.4Assay Description:The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...More data for this Ligand-Target Pair
Affinity DataIC50: 14.2nMpH: 7.4Assay Description:The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...More data for this Ligand-Target Pair