BDBM107471 US8592410, 10

SMILES C[C@H](N1CC[C@@](CCCO)(OC1=O)c1ccc(F)cc1)c1ccc(cc1)-c1ccc(=O)n(C)n1

InChI Key InChIKey=GBRWFLMEKQVFJW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 107471   

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM107471(US8592410, 10)
Affinity DataIC50: 1.90nMAssay Description:The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2014
Entry Details
Go to US Patent

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM107471(US8592410, 10)
Affinity DataIC50: 8.04nMAssay Description:The inhibition assay using 11β-HSD1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2014
Entry Details
Go to US Patent

TargetCytochrome P450 2C9(Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM107471(US8592410, 10)
Affinity DataIC50: 1.42E+4nMAssay Description:The inhibition of recombinant CYP2C9 by compounds of the invention was measured using a commercial kit from Invitrogen (cat #2859).More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2014
Entry Details
Go to US Patent