BDBM107112 US8592423, 2-(2-(1-Ethyl-4-phenyl-1H-imidazol-2-yl)cyclopropyl)-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine

SMILES CCn1cc(nc1C1CC1c1nc2c(C)ncc(C)n2n1)-c1ccccc1

InChI Key InChIKey=CISKNCAOUCLBQG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 107112   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107112(US8592423, 2-(2-(1-Ethyl-4-phenyl-1H-imidazol-2-yl...)
Affinity DataIC50: 1.79nMAssay Description:PDE10 activity was measured using Scintillation Proximity Assay (SPA)-based methods. PDE10 catalyses the hydrolysis of the intracellular messenger ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2014
Entry Details
Go to US Patent