BDBM106565 US8586600, II-45

SMILES Cc1ccc(NC(=O)c2ccc3CN(CCc3c2)C(=O)C=C)cc1Nc1nccc(n1)-c1cccnc1

InChI Key InChIKey=PUEYPRPLOZAKPF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 106565   

TargetPlatelet-derived growth factor receptor alpha(Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM106565(US8586600, II-45)
Affinity DataIC50: 7.90nMAssay Description:Compounds may also be assayed as inhibitors of PDGFR in a manner substantially similar to the method described in Roberts, et al., “Antiangiogen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2014
Entry Details
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TargetVascular endothelial growth factor receptor 2(Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM106565(US8586600, II-45)
Affinity DataIC50: 1.00E+4nMAssay Description:Compounds may be screened for their ability to inhibit KDR using a standard coupled enzyme assay (Fox et al., Protein Sci., (1998) 7, 2249).More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2014
Entry Details
Go to US Patent