BDBM106562 US8586600, III-14

SMILES Cc1ccc(cc1Nc1nccc(n1)-c1cccnc1)C(=O)Nc1ccc(NC(=O)CCl)c(c1)C(F)(F)F

InChI Key InChIKey=ZKFZKBXDZAXEBR-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 106562   

TargetPlatelet-derived growth factor receptor alpha(Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM106562(US8586600, III-14)
Affinity DataIC50: 0.730nMAssay Description:Compounds may also be assayed as inhibitors of PDGFR in a manner substantially similar to the method described in Roberts, et al., “Antiangiogen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2014
Entry Details
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TargetMast/stem cell growth factor receptor Kit(Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM106562(US8586600, III-14)
Affinity DataIC50: 2.01E+3nMAssay Description:Compounds may also be assayed as inhibitors of CKit in a manner substantially similar to the method described by Upstate (http://www.upstate.com/img/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2014
Entry Details
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TargetMast/stem cell growth factor receptor Kit(Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM106562(US8586600, III-14)
Affinity DataIC50: 72nMAssay Description:Compounds may also be assayed as inhibitors of CKit in a manner substantially similar to the method described by Upstate (http://www.upstate.com/img/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2014
Entry Details
Go to US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM106562(US8586600, III-14)
Affinity DataIC50: 72.4nMAssay Description:Compounds may also be assayed as inhibitors of CKit in a manner substantially similar to the method described by Upstate (http://www.upstate.com/img/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2014
Entry Details
Go to US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM106562(US8586600, III-14)
Affinity DataIC50: 205nMAssay Description:Compounds may also be assayed as inhibitors of CKit in a manner substantially similar to the method described by Upstate (http://www.upstate.com/img/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2014
Entry Details
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TargetVascular endothelial growth factor receptor 2(Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM106562(US8586600, III-14)
Affinity DataIC50: 2.10E+3nMAssay Description:Compounds may be screened for their ability to inhibit KDR using a standard coupled enzyme assay (Fox et al., Protein Sci., (1998) 7, 2249).More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2014
Entry Details
Go to US Patent