BDBM106560 US8586600, II-55

SMILES CN(C)C\C=C\C(=O)Nc1ccc(cc1C(F)(F)F)C(=O)Nc1ccc(C)c(Nc2nccc(n2)-c2cccnc2)c1

InChI Key InChIKey=CSQMNCNSZXFMCT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 106560   

TargetVascular endothelial growth factor receptor 2(Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM106560(US8586600, II-55)
Affinity DataIC50: 4.50E+3nMAssay Description:Compounds may be screened for their ability to inhibit KDR using a standard coupled enzyme assay (Fox et al., Protein Sci., (1998) 7, 2249).More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2014
Entry Details
Go to US Patent

TargetPlatelet-derived growth factor receptor alpha(Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM106560(US8586600, II-55)
Affinity DataIC50: 1.40nMAssay Description:Compounds may also be assayed as inhibitors of PDGFR in a manner substantially similar to the method described in Roberts, et al., “Antiangiogen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2014
Entry Details
Go to US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM106560(US8586600, II-55)
Affinity DataIC50: 9.15E+3nMAssay Description:Compounds may also be assayed as inhibitors of CKit in a manner substantially similar to the method described by Upstate (http://www.upstate.com/img/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2014
Entry Details
Go to US Patent