BDBM106553 US8586600, II-2

SMILES Cc1ccc(NC(=O)c2ccc(NC(=O)C=C)c(c2)C(F)(F)F)cc1Nc1nccc(n1)-c1cccnc1

InChI Key InChIKey=IKQQCPGYCMFUKJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 106553   

TargetPlatelet-derived growth factor receptor alpha(Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM106553(US8586600, II-2)
Affinity DataIC50: 2.20nMAssay Description:Compounds may also be assayed as inhibitors of PDGFR in a manner substantially similar to the method described in Roberts, et al., “Antiangiogen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2014
Entry Details
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TargetMast/stem cell growth factor receptor Kit(Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM106553(US8586600, II-2)
Affinity DataIC50: 83nMAssay Description:Compounds may also be assayed as inhibitors of CKit in a manner substantially similar to the method described by Upstate (http://www.upstate.com/img/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2014
Entry Details
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TargetVascular endothelial growth factor receptor 2(Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM106553(US8586600, II-2)
Affinity DataIC50: 3.00E+3nMAssay Description:Compounds may be screened for their ability to inhibit KDR using a standard coupled enzyme assay (Fox et al., Protein Sci., (1998) 7, 2249).More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2014
Entry Details
Go to US Patent