BDBM10586 3-Chloro-6,7,10,11-tetrahydro-9-methyl-12-{{3-{N-{3-[(1,2,3,4-tetrahydroacridin-9-yl)amino]propyl}-N-methylamino}propyl}amino}-7,11-methanocycloocta[b]quinoline trihydrochloride::CHEMBL2011487::Huprine-Tacrine Heterodimer 17d::[3-({7-chloro-15-methyl-10-azatetracyclo[11.3.1.0^{2,11}.0^{4,9}]heptadeca-2(11),3,5,7,9,14-hexaen-3-yl}amino)propyl](methyl)[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]amine trihydrochloride

SMILES CN(CCCNc1c2CCCCc2nc2ccccc12)CCCNc1c2C3CC(Cc2nc2cc(Cl)ccc12)C=C(C)C3

InChI Key InChIKey=YFDJQAZBRSGJIT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 10586   

TargetAcetylcholinesterase(Human)
Universitat De Barcelona

LigandPNGBDBM10586([3-({7-chloro-15-methyl-10-azatetracyclo[11.3.1.0^...)
Affinity DataIC50: 0.320nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2006
Entry Details Article
PubMed
TargetCholinesterase(Human)
Universitat De Barcelona

LigandPNGBDBM10586([3-({7-chloro-15-methyl-10-azatetracyclo[11.3.1.0^...)
Affinity DataIC50: 16.4nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Universitat De Barcelona

LigandPNGBDBM10586([3-({7-chloro-15-methyl-10-azatetracyclo[11.3.1.0^...)
Affinity DataIC50: 0.420nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCholinesterase(Human)
Universitat De Barcelona

LigandPNGBDBM10586([3-({7-chloro-15-methyl-10-azatetracyclo[11.3.1.0^...)
Affinity DataIC50: 44nMAssay Description:Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed