BDBM105503 US10047086, 71::US10640503, Example 71::US9695168, 71

SMILES CN1CCC[C@@H](COc2cc(-c3ccc(cc3)C#N)c(-c3ccc(nc3)N3CCCC3=O)n3cncc23)C1

InChI Key InChIKey=ZTTJJXDXAKXKKG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 105503   

LigandPNGBDBM105503(US9695168, 71 | US10047086, 71 | US10640503, Examp...)
Affinity DataIC50: 50nMpH: 7.5 T: 2°CAssay Description:LANCE LSD1/KDM1A demethylase assay 10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2018
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Incyte

US Patent
LigandPNGBDBM105503(US9695168, 71 | US10047086, 71 | US10640503, Examp...)
Affinity DataIC50: 50nMpH: 7.5Assay Description:LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2018
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Incyte

US Patent
LigandPNGBDBM105503(US9695168, 71 | US10047086, 71 | US10640503, Examp...)
Affinity DataIC50: 50nMAssay Description:LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2021
Entry Details
Go to US Patent