BDBM104716 US8569308, 136

SMILES Clc1cccc(c1)C(=O)Nc1cncc(Oc2cccnc2)n1

InChI Key InChIKey=CSOLVKRGZBHTRO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 104716   

TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt University

US Patent
LigandPNGBDBM104716(US8569308, 136)
Affinity DataIC50: 100nMAssay Description:The mGluR5 activity was determined using the metabotropic glutamate receptor activity assays in human embryonic kidney cell.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2014
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM104716(US8569308, 136)
Affinity DataIC50: 129nMAssay Description:Negative allosteric modulator activity at rat mGlu5 expressed in HEK293A cells assessed as reduction in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM104716(US8569308, 136)
Affinity DataIC50: 129nMAssay Description:Negative allosteric modulator activity at rat mGlu5 expressed in HEK293A cells assessed as reduction in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed