BDBM104493 US8575114, I-5

SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cn2nc3ccc(cn3c2=O)C(F)(F)F)c1

InChI Key InChIKey=TXXJMDCSAIEKEQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 104493   

TargetSodium/glucose cotransporter 2(Human)
Albany Molecular Research

US Patent
LigandPNGBDBM104493(US8575114, I-5)
Affinity DataIC50: 991nMAssay Description:The inhibitory activity of the compounds of this invention against the SGLT-1 or SGLT-2 transporters.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2014
Entry Details
Go to US Patent

TargetSodium/glucose cotransporter 1(Human)
Albany Molecular Research

US Patent
LigandPNGBDBM104493(US8575114, I-5)
Affinity DataIC50: 9.00E+4nMAssay Description:The inhibitory activity of the compounds of this invention against the SGLT-1 or SGLT-2 transporters.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2014
Entry Details
Go to US Patent

TargetSodium/glucose cotransporter 2(Human)
Albany Molecular Research

US Patent
LigandPNGBDBM104493(US8575114, I-5)
Affinity DataIC50: 762nMAssay Description:Inhibition of human SGLT2 expressed in CHOK1 cells assessed as inhibition of [14C]-AMG uptake after 3 hrs by microbeta scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Albany Molecular Research

US Patent
LigandPNGBDBM104493(US8575114, I-5)
Affinity DataIC50: 9.00E+4nMAssay Description:Inhibition of human SGLT1 expressed in CHOK1 cells assessed as inhibition of [14C]-AMG uptake after 3 hrs by microbeta scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed