BDBM104490 US8575114, I-2

SMILES Cc1ccc2nn(Cc3cc(ccc3Cl)[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c(=O)n2c1

InChI Key InChIKey=ZVCWTCOSNLVQCJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 104490   

TargetSodium/glucose cotransporter 2(Human)
Albany Molecular Research

US Patent
LigandPNGBDBM104490(US8575114, I-2)
Affinity DataIC50: 129nMAssay Description:The inhibitory activity of the compounds of this invention against the SGLT-1 or SGLT-2 transporters.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2014
Entry Details
Go to US Patent

TargetSodium/glucose cotransporter 1(Human)
Albany Molecular Research

US Patent
LigandPNGBDBM104490(US8575114, I-2)
Affinity DataIC50: 6.74E+4nMAssay Description:The inhibitory activity of the compounds of this invention against the SGLT-1 or SGLT-2 transporters.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2014
Entry Details
Go to US Patent

TargetSodium/glucose cotransporter 2(Human)
Albany Molecular Research

US Patent
LigandPNGBDBM104490(US8575114, I-2)
Affinity DataIC50: 120nMAssay Description:Inhibition of human SGLT2 expressed in CHOK1 cells assessed as inhibition of [14C]-AMG uptake after 3 hrs by microbeta scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Albany Molecular Research

US Patent
LigandPNGBDBM104490(US8575114, I-2)
Affinity DataIC50: 9.00E+4nMAssay Description:Inhibition of human SGLT1 expressed in CHOK1 cells assessed as inhibition of [14C]-AMG uptake after 3 hrs by microbeta scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed