BDBM103878 US10125133, Example 5::US10968221, Example 5::US9695167, 5

SMILES Cc1ccc(cc1)-c1c(cc(-c2cccc(CN3CCC(N)C3)c2)c2ncnn12)-c1ccc(cc1)C#N

InChI Key InChIKey=OTNUJQPXKKRFIH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 103878   

LigandPNGBDBM103878(US9695167, 5 | US10125133, Example 5 | US10968221,...)
Affinity DataIC50: 75nMpH: 7.5 T: 2°CAssay Description:LANCE LSD1/KDM1A demethylase assay 10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2018
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Incyte

US Patent
LigandPNGBDBM103878(US9695167, 5 | US10125133, Example 5 | US10968221,...)
Affinity DataIC50: 75nMAssay Description:LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Incyte

US Patent
LigandPNGBDBM103878(US9695167, 5 | US10125133, Example 5 | US10968221,...)
Affinity DataIC50: 75nMAssay Description:LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent