BDBM103760 US8551978, I-29::US8816088, I-29::US9394275, I-29::US9572802, Compound I-29::US9682957, I-29

SMILES COc1cc(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)ccc1NC(=O)c1cccc(c1)N(C)C(=O)CCN1CCC(CC1)OC(=O)Nc1ccccc1-c1ccccc1

InChI Key InChIKey=GRKMMSVOPAFSBE-UHFFFAOYSA-N

Data  5 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 103760   

TargetBeta-2 adrenergic receptor(Human)
Theravance Respiratory

US Patent
LigandPNGBDBM103760(US8816088, I-29 | US8551978, I-29 | US9682957, I-2...)
Affinity DataEC50:  1nMT: 2°CAssay Description:cAMP assays were performed in a radioimmunoassay format using the Flashplate Adenylyl Cyclase Activation Assay System with [125I]-cAMP (NEN SMP004, P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details
Go to US Patent

TargetBeta-2 adrenergic receptor(Human)
Theravance Respiratory

US Patent
LigandPNGBDBM103760(US8816088, I-29 | US8551978, I-29 | US9682957, I-2...)
Affinity DataEC50:  1nMT: 2°CAssay Description:cAMP assays were performed in a radioimmunoassay format using the Flashplate Adenylyl Cyclase Activation Assay System with [125I]-cAMP (NEN SMP004, P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Theravance

US Patent
LigandPNGBDBM103760(US8816088, I-29 | US8551978, I-29 | US9682957, I-2...)
Affinity DataKi:  0.100nMAssay Description:Radioligand binding assay using muscarinic receptors.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
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TargetMuscarinic acetylcholine receptor M3(Human)
Theravance

US Patent
LigandPNGBDBM103760(US8816088, I-29 | US8551978, I-29 | US9682957, I-2...)
Affinity DataKi:  0.100nMAssay Description:Radioligand binding assays for cloned muscarinic receptors were performed in 96-well microtiter plates in a total assay volume of 100 uL. CHO cell me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2015
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Theravance

US Patent
LigandPNGBDBM103760(US8816088, I-29 | US8551978, I-29 | US9682957, I-2...)
Affinity DataKi:  0.100nM ΔG°:  -14.2kcal/moleT: 2°CAssay Description:Displacement assays for determination of Ki values of test compounds were performed with [3H]-NMS at 1 nM and eleven different test compound concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Theravance

US Patent
LigandPNGBDBM103760(US8816088, I-29 | US8551978, I-29 | US9682957, I-2...)
Affinity DataKi:  0.100nMAssay Description:Radioligand binding assays for cloned muscarinic receptors were performed in 96-well microtiter plates in a total assay volume of 100 μL. CHO ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2018
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Theravance

US Patent
LigandPNGBDBM103760(US8816088, I-29 | US8551978, I-29 | US9682957, I-2...)
Affinity DataKi:  0.100nMAssay Description:compounds were performed with [3H]NMS at 1 nM and eleven different test compound concentrations. The test compounds were initially dissolved to a con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
Go to US Patent