BDBM103575 ATX inhibitor 10 analogue 5::US8551988, 65

SMILES B(c1cccc(c1)CN2CCN(CC2)C3=NC(=O)/C(=C/c4ccc(c(c4)Cl)Cl)/S3)(O)O

InChI Key InChIKey=ZCKGWOBAJNWRNC-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 103575   

LigandPNGBDBM103575(ATX inhibitor 10 analogue 5 | US8551988, 65)
Affinity DataIC50: 13nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAutotaxin(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM103575(ATX inhibitor 10 analogue 5 | US8551988, 65)
Affinity DataIC50: 13nMAssay Description:Inhibition of human recombinant ATXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAutotaxin(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM103575(ATX inhibitor 10 analogue 5 | US8551988, 65)
Affinity DataIC50: 13nMAssay Description:Inhibition of ATX (unknown origin) expressed in human HEK293 cells using TG-mTMP as substrate after 2 hrs by fluorescence based plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)