BDBM10312 (S)-5-{1-[(2-Methoxycarbonyl)pyrrolidinyl]sulfonyl}isatin::Isatin Sulfonamide 23::methyl (2S)-1-[(2,3-dioxo-2,3-dihydro-1H-indole-5-)sulfonyl]pyrrolidine-2-carboxylate

SMILES COC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2NC(=O)C(=O)c2c1

InChI Key InChIKey=YVTSUCCABJRHGQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 10312   

TargetCaspase-3(Human)
Glaxosmithkline

LigandPNGBDBM10312(methyl (2S)-1-[(2,3-dioxo-2,3-dihydro-1H-indole-5-...)
Affinity DataIC50: 170nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Glaxosmithkline

LigandPNGBDBM10312(methyl (2S)-1-[(2,3-dioxo-2,3-dihydro-1H-indole-5-...)
Affinity DataIC50: 170nMAssay Description:Inhibition of caspase 3 in human SK-N-SH cells assessed as accumulation of fluorogenic 7-amino-4-methyl coumarin by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed