BDBM102980 US8546435, 8

SMILES COc1ccc(Cn2c(nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)[C@@H](Cc2c[nH]c3ccccc23)NC(C)=O)cc1

InChI Key InChIKey=OMEYXMRIYJZPAD-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 102980   

TargetGrowth hormone secretagogue receptor type 1(Human)
Aeterna Zentaris

US Patent
LigandPNGBDBM102980(US8546435, 8)
Affinity DataIC50: 1.40nMAssay Description:Competitive binding assay using ghrelin receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2013
Entry Details
Go to US Patent

TargetGrowth hormone secretagogue receptor type 1(Human)
Aeterna Zentaris

US Patent
LigandPNGBDBM102980(US8546435, 8)
Affinity DataIC50: 22nMAssay Description:Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and roli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2017
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Aeterna Zentaris

US Patent
LigandPNGBDBM102980(US8546435, 8)
Affinity DataIC50: 19nMAssay Description:Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2017
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Aeterna Zentaris

US Patent
LigandPNGBDBM102980(US8546435, 8)
Affinity DataKi:  12nMAssay Description:Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2017
Entry Details Article
PubMed