BDBM102218 US9695165, 20

SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cccc(NC(=O)C=C)c1

InChI Key InChIKey=RZXDKZLFCJLLNW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 102218   

TargetFibroblast growth factor receptor 4(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM102218(US9695165, 20)
Affinity DataIC50: 10nMpH: 7.5 T: 2°CAssay Description:In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2018
Entry Details
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TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM102218(US9695165, 20)
Affinity DataIC50: 10nMAssay Description:MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2018
Entry Details
Go to US Patent