BDBM10108 4-alkynyl oxindole 7n::N-[(3R,4R)-1-[(3Z)-5-fluoro-3-[(3-methoxy-1H-pyrrol-2-yl)methylidene]-2-oxo-2,3-dihydro-1H-indol-4-yl]-4-hydroxypent-1-yn-3-yl]methanesulfonamide

SMILES COc1cc[nH]c1\C=C1/C(=O)Nc2ccc(F)c(C#C[C@@H](NS(C)(=O)=O)[C@@H](C)O)c12

InChI Key InChIKey=OUNCSFZWBHZJNV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 10108   

LigandPNGBDBM10108(N-[(3R,4R)-1-[(3Z)-5-fluoro-3-[(3-methoxy-1H-pyrro...)
Affinity DataIC50: 45nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed using a recombinant human cyclin E-CDK2 complex. The enzyme was assayed with substrate in the presence of 1uM ATP/[gamma...More data for this Ligand-Target Pair
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Date in BDB:
6/27/2006
Entry Details Article
PubMed