BDBM50017478 Amastatin::CHEMBL28650::Leu[1psi,CHOHCONH]ValValAsp::N-[(2S,3R)-3-amino-2-hydroxy-5-methylhexanoyl]-L-valyl-L-valyl-L-aspartic acid

SMILES CC(C)C[C@@H](N)[C@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O

InChI Key InChIKey=QFAADIRHLBXJJS-UHFFFAOYSA-N

Data  11 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50017478   

TargetAminopeptidase N(Pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50017478(CHEMBL28650 | Amastatin | Leu[1psi,CHOHCONH]ValVal...)
Affinity DataIC50: 1.10E+3nMAssay Description:Compound was evaluated for the inhibitory activity against aminopeptidase MMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetLeucyl-cystinyl aminopeptidase(Rat)
University of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50017478(CHEMBL28650 | Amastatin | Leu[1psi,CHOHCONH]ValVal...)
Affinity DataKi:  20nMAssay Description:Inhibition of aminopeptidase M or membrane leucine aminopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetAminopeptidase N(Pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50017478(CHEMBL28650 | Amastatin | Leu[1psi,CHOHCONH]ValVal...)
Affinity DataKi:  20nMAssay Description:Compound was evaluated for the inhibition of Aminopeptidase M (AP-M) and the inhibition constant was determined after preincubating the enzyme and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetAminopeptidase N(Pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50017478(CHEMBL28650 | Amastatin | Leu[1psi,CHOHCONH]ValVal...)
Affinity DataKi:  20nMAssay Description:Effect of inhibitor structure on the slow binding inhibition of aminopeptidase M was determined and Ki* was reported which is obtained by the equatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetCytosol aminopeptidase(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50017478(CHEMBL28650 | Amastatin | Leu[1psi,CHOHCONH]ValVal...)
Affinity DataKi:  30nMAssay Description:Binding affinity for cytosolic leucine aminopeptidase (LAP) from porcine kidneyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetCytosol aminopeptidase(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50017478(CHEMBL28650 | Amastatin | Leu[1psi,CHOHCONH]ValVal...)
Affinity DataKi:  200nMAssay Description:Effect of inhibitor structure on the slow binding inhibition of Leucine aminopeptidase was determined and the Ki was reported which is = k2/k1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetAminopeptidase N(Human)
University of Paris

Curated by ChEMBL
LigandPNGBDBM50017478(CHEMBL28650 | Amastatin | Leu[1psi,CHOHCONH]ValVal...)
Affinity DataKi:  200nMAssay Description:Inhibition of aminopeptidase N (APN)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetLeucyl-cystinyl aminopeptidase(Rat)
University of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50017478(CHEMBL28650 | Amastatin | Leu[1psi,CHOHCONH]ValVal...)
Affinity DataKi:  220nMAssay Description:Inhibition of leucine aminopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetCytosol aminopeptidase(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50017478(CHEMBL28650 | Amastatin | Leu[1psi,CHOHCONH]ValVal...)
Affinity DataKi:  220nMAssay Description:Compound was evaluated for the inhibition of Leucine aminopeptidase and the inhibition constant was determined after preincubating the enzyme and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetAminopeptidase N(Pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50017478(CHEMBL28650 | Amastatin | Leu[1psi,CHOHCONH]ValVal...)
Affinity DataKi:  2.00E+3nMAssay Description:Effect of inhibitor structure on the slow binding inhibition of aminopeptidase M was determined and the Ki was reported which is = k2/k1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetGlutamyl aminopeptidase(Human)
University of Paris

Curated by ChEMBL
LigandPNGBDBM50017478(CHEMBL28650 | Amastatin | Leu[1psi,CHOHCONH]ValVal...)
Affinity DataKi:  8.00E+3nMAssay Description:Inhibition of aminopeptidase A (APA)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetCytosol aminopeptidase(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50017478(CHEMBL28650 | Amastatin | Leu[1psi,CHOHCONH]ValVal...)
Affinity DataKi:  2.00E+4nMAssay Description:Effect of inhibitor structure on the slow binding inhibition of Leucine aminopeptidase was determined and Ki* was reported which is obtained by the e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed