BDBM50457967 Abelcet::Ambisome::Amophotericin B::Ampho-Moronal::Amphotec::Amphotercin B::Amphotericin::Amphotericin B::Amphotericin b lipid complex::Amphotericin b liposomal complex::Amphotericine B::Amphotericitin B::Amphotreicin B::Ampotericin B::CHEBI:2682::Fungilin::Fungilin In Orabase::Fungizone::NSC-527017

SMILES [H][C@]12C[C@@H](O[C@]3([H])O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]1C(O)=O)O2

InChI Key InChIKey=APKFDSVGJQXUKY-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50457967   

TargetCytochrome P450 2C19(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50457967(CHEBI:2682 | Abelcet | Ambisome | Amophotericin B ...)
Affinity DataIC50: 9.60E+4nMAssay Description:Inhibition of human microsomal CYP2C19 expressed in baculovirus infected BTI-TN-5B1-4 cells incubated for 30 mins by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50457967(CHEBI:2682 | Abelcet | Ambisome | Amophotericin B ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human microsomal CYP2C9 expressed in baculovirus infected BTI-TN-5B1-4 cells incubated for 30 mins by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50457967(CHEBI:2682 | Abelcet | Ambisome | Amophotericin B ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERG incubated for 2 hrs by fluorescence polarisation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50457967(CHEBI:2682 | Abelcet | Ambisome | Amophotericin B ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human microsomal CYP1A2 expressed in baculovirus infected BTI-TN-5B1-4 cells incubated for 30 mins by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAurora kinase B(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50457967(CHEBI:2682 | Abelcet | Ambisome | Amophotericin B ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant full-length human aurora B kinase expressed in baculovirus system using MBP as substrate incubated for 45 mins by ADP-glo k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50457967(CHEBI:2682 | Abelcet | Ambisome | Amophotericin B ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human microsomal CYP2D6 expressed in baculovirus infected BTI-TN-5B1-4 cells incubated for 30 mins by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50457967(CHEBI:2682 | Abelcet | Ambisome | Amophotericin B ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human microsomal CYP3A4 expressed in baculovirus infected BTI-TN-5B1-4 cells incubated for 30 mins by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Federal University of Parana

Curated by ChEMBL
LigandPNGBDBM50457967(CHEBI:2682 | Abelcet | Ambisome | Amophotericin B ...)
Affinity DataIC50: 1.27E+5nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in human HEK293 cells membrane vesicles assessed inhibition of BCRP- mediated transport of 3[H]-E1S fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed