BDBM50268741 8-(2,6-dimethylbenzylamino)-N-(2-hydroxyethyl)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide::AZD-0865::CHEMBL497011

SMILES Cc1nc2c(NCc3c(C)cccc3C)cc(cn2c1C)C(=O)NCCO

InChI Key InChIKey=GHVIMBCFLRTFHI-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50268741   

TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50268741(8-(2,6-dimethylbenzylamino)-N-(2-hydroxyethyl)-2,3...)
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of CYP3A4 using diethoxyfluorescein as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50268741(8-(2,6-dimethylbenzylamino)-N-(2-hydroxyethyl)-2,3...)
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50268741(8-(2,6-dimethylbenzylamino)-N-(2-hydroxyethyl)-2,3...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50268741(8-(2,6-dimethylbenzylamino)-N-(2-hydroxyethyl)-2,3...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of CYP3A4 using 7-benzyloxyquinoline as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50268741(8-(2,6-dimethylbenzylamino)-N-(2-hydroxyethyl)-2,3...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50268741(8-(2,6-dimethylbenzylamino)-N-(2-hydroxyethyl)-2,3...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50268741(8-(2,6-dimethylbenzylamino)-N-(2-hydroxyethyl)-2,3...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of CYP3A4 using 7-benzyloxyquinoline substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50268741(8-(2,6-dimethylbenzylamino)-N-(2-hydroxyethyl)-2,3...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of CYP3A4 using diethoxyfluorescein substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50268741(8-(2,6-dimethylbenzylamino)-N-(2-hydroxyethyl)-2,3...)
Affinity DataIC50: 5.80E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50268741(8-(2,6-dimethylbenzylamino)-N-(2-hydroxyethyl)-2,3...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50268741(8-(2,6-dimethylbenzylamino)-N-(2-hydroxyethyl)-2,3...)
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50268741(8-(2,6-dimethylbenzylamino)-N-(2-hydroxyethyl)-2,3...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50268741(8-(2,6-dimethylbenzylamino)-N-(2-hydroxyethyl)-2,3...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2019
Entry Details Article
PubMed