BDBM32147 AS-229::CHLOROXINE::cid_2722

SMILES Oc1c(Cl)cc(Cl)c2cccnc12

InChI Key InChIKey=WDFKMLRRRCGAKS-UHFFFAOYSA-N

Data  15 IC50  2 Kd  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 32147   

TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM32147(AS-229 | cid_2722 | CHLOROXINE)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of human reticulocyte N-terminally His6-tagged 15-lipoxygenase-2 assessed as conjugated diene product formation using arachidonic acid by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Freie University Berlin

Curated by ChEMBL
LigandPNGBDBM32147(AS-229 | cid_2722 | CHLOROXINE)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of C-terminal 6His-tagged full length NDM-1 (unknown origin) expressed in Escherichia coli BL21-DE3 using nitrocefin as substrate incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCollagenase 3(Human)
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM32147(AS-229 | cid_2722 | CHLOROXINE)
Affinity DataIC50: 1.96E+4nMAssay Description:Inhibition of MMP-13 (unknown origin) using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as fluorogenic substrate preincubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMatrix metalloproteinase-9(Human)
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM32147(AS-229 | cid_2722 | CHLOROXINE)
Affinity DataIC50: 1.59E+4nMAssay Description:Inhibition of MMP-9 (unknown origin) using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as fluorogenic substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMatrix metalloproteinase-14(Human)
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM32147(AS-229 | cid_2722 | CHLOROXINE)
Affinity DataKd:  2.40E+3nMAssay Description:Binding affinity to CMS sensor chip immobilized MMP-14 catalytic domain (unknown origin) assessed as equilibrium dissociation constant by surface pla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMatrix metalloproteinase-14(Human)
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM32147(AS-229 | cid_2722 | CHLOROXINE)
Affinity DataIC50: 2.56E+4nMAssay Description:Inhibition of MMP-14 (unknown origin) using 5-FAM-TDVPNGFHVS (QXL520)-NH2 as fluorogenic substrate preincubated for 10 mins followed by substrate add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The State University of New Jersey

Curated by ChEMBL
LigandPNGBDBM32147(AS-229 | cid_2722 | CHLOROXINE)
Affinity DataKd:  4.60E+3nMAssay Description:Binding affinity to biotin-tagged SARS-CoV-2 papain-like protease expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The State University of New Jersey

Curated by ChEMBL
LigandPNGBDBM32147(AS-229 | cid_2722 | CHLOROXINE)
Affinity DataIC50: 7.24E+3nMAssay Description:Inhibition of 6xHis-tagged SARS-CoV-2 papain-like protease expressed in Escherichia coli BL21 (DE3) using ISG15-FITC as substrate incubated for 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM32147(AS-229 | cid_2722 | CHLOROXINE)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of HIV-1 integrase strand transfer activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM32147(AS-229 | cid_2722 | CHLOROXINE)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of HIV-1 integrase 3'-processing activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM32147(AS-229 | cid_2722 | CHLOROXINE)
Affinity DataIC50: 1.15E+4nMAssay Description:Inhibition of Clostridium botulinum BoNT/A LC expressed in Escherichia coli assessed as cleavage of SNAPtide preincubated for 5 mins followed by SNAP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM32147(AS-229 | cid_2722 | CHLOROXINE)
Affinity DataIC50: 5.00E+4nMpH: 7.4 T: 2°CAssay Description:A fluorescence polarization based HTS assay has been developed and optimized for the identification of Hsp90 inhibitors by using tumor cell lysate Hs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2009
Entry Details
PCBioAssay
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM32147(AS-229 | cid_2722 | CHLOROXINE)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of human reticulocyte N-terminally His6-tagged 15-lipoxygenase-1 assessed as conjugated diene product formation using arachidonic acid by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM32147(AS-229 | cid_2722 | CHLOROXINE)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of human 5-lipoxygenase assessed as conjugated diene product formation using arachidonic acid by UV-vis spectrophotometer analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM32147(AS-229 | cid_2722 | CHLOROXINE)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human platelet-type N-terminally His6-tagged 12-lipoxygenase assessed as conjugated diene product formation using arachidonic acid by U...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
National Institutes of Health Chemical Genomics Center

Curated by ChEMBL
LigandPNGBDBM32147(AS-229 | cid_2722 | CHLOROXINE)
Affinity DataEC50:  3.98E+4nMAssay Description:Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Southern Research Institute

Curated by PubChem BioAssay
LigandPNGBDBM32147(AS-229 | cid_2722 | CHLOROXINE)
Affinity DataEC50: >5.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details
PCBioAssay
TargetAmmonium transporter MEP2(Baker's yeast)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM32147(AS-229 | cid_2722 | CHLOROXINE)
Affinity DataEC50:  3.61E+7nMAssay Description:University of New Mexico Assay Overview: Assay Support: 1R03 MH086450-01 Project Title: Chemical Screen of TOR pathway GFP fusion proteins in S. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2011
Entry Details
PCBioAssay
TargetCitrate synthase, peroxisomal [1-24](Baker's yeast)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM32147(AS-229 | cid_2722 | CHLOROXINE)
Affinity DataEC50:  1.98E+7nMAssay Description:University of New Mexico Assay Overview: Assay Support: 1R03 MH086450-01 Project Title: Chemical Screen of TOR pathway GFP fusion proteins in S. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2011
Entry Details
PCBioAssay
TargetKappa-type opioid receptor(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM32147(AS-229 | cid_2722 | CHLOROXINE)
Affinity DataIC50: 4.56E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
TargetHeat shock protein HSP 90-alpha(Human)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM32147(AS-229 | cid_2722 | CHLOROXINE)
Affinity DataIC50: 5.00E+4nMpH: 7.4 T: 2°CAssay Description:A fluorescence polarization based HTS assay has been developed and optimized for the identification of Hsp90 inhibitors by using tumor cell lysate Hs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2009
Entry Details
PCBioAssay