BDBM50146168 ARQ-197::Tivantinib

SMILES c1ccc2c(c1)c(c[nH]2)[C@H]3[C@@H](C(=O)NC3=O)c4cn5c6c4cccc6CCC5

InChI Key InChIKey=UCEQXRCJXIVODC-UHFFFAOYSA-N

Data  4 KI  1 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50146168   

TargetHepatocyte growth factor receptor(Human)
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM50146168(ARQ-197 | Tivantinib)
Affinity DataIC50: 360nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM50146168(ARQ-197 | Tivantinib)
Affinity DataKi:  335nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM50146168(ARQ-197 | Tivantinib)
Affinity DataKi:  355nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2017
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM50146168(ARQ-197 | Tivantinib)
Affinity DataKi:  355nMAssay Description:Inhibition of recombinant human c-Met (974 to 1390 residues) using poly-Glu-Tyr as substrate preincubated for 20 mins followed by substrate and [gamm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM50146168(ARQ-197 | Tivantinib)
Affinity DataKi:  355nMAssay Description:Binding affinity to human recombinant MET assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed