BDBM50475225 (S)-HDAC 42::(S)-HDAC-42::AR42::Ar-42

SMILES CC(C)[C@@H](c1ccccc1)C(=O)Nc2ccc(cc2)C(=O)NO

InChI Key InChIKey=LAMIXXKAWNLXOC-UHFFFAOYSA-N

Data  6 IC50

PDB links: 4 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50475225   

TargetHistone deacetylase(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50475225((S)-HDAC 42 | (S)-HDAC-42 | AR42 | Ar-42)
Affinity DataIC50: 16nMAssay Description:In vitro inhibitory concentration against histone deacetylase of DU-145 prostate cell nuclear extract as deacetylation of biotinylated [3H]-acetyl hi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50475225((S)-HDAC 42 | (S)-HDAC-42 | AR42 | Ar-42)
Affinity DataIC50: 430nMAssay Description:Inhibition of recombinant human HDAC7 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50475225((S)-HDAC 42 | (S)-HDAC-42 | AR42 | Ar-42)
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-LGK(Ac)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured after 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50475225((S)-HDAC 42 | (S)-HDAC-42 | AR42 | Ar-42)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of recombinant human HDAC6 using Boc-Lys(Ac)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50475225((S)-HDAC 42 | (S)-HDAC-42 | AR42 | Ar-42)
Affinity DataIC50: 170nMAssay Description:Inhibition of recombinant human HDAC8 using Ac-LGK(TFA)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured after 9...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50475225((S)-HDAC 42 | (S)-HDAC-42 | AR42 | Ar-42)
Affinity DataIC50: 300nMAssay Description:Inhibition of Class 1 histone deacetylase in human THP-1 cells using Ac-LGK(Ac)-AMC as substrate incubated for 3 hrs followed by 50 uM SAHA addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed