BDBM50285941 APD-371::Olorinab

SMILES [H][C@@]12C[C@]1([H])c1c(C2)c(nn1-c1c[n+]([O-])ccn1)C(=O)N[C@H](CO)C(C)(C)C

InChI Key InChIKey=ACSQLTBPYZSGBA-UHFFFAOYSA-N

Data  7 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50285941   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50285941(APD-371 | Olorinab)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of [3H]-astemizole binding to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50285941(APD-371 | Olorinab)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50285941(APD-371 | Olorinab)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50285941(APD-371 | Olorinab)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50285941(APD-371 | Olorinab)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50285941(APD-371 | Olorinab)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG by patch-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Rat)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50285941(APD-371 | Olorinab)
Affinity DataEC50:  7.60nMAssay Description:Agonist activity at recombinant rat CB2 receptor expressed in HEK293 cells assessed as increase in beta arrestin recruitment measured after 2 to 3 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50285941(APD-371 | Olorinab)
Affinity DataEC50:  6.20nMAssay Description:Agonist activity at recombinant human CB2 receptor expressed in HEK293 cells assessed as increase in beta arrestin recruitment measured after 2 to 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50285941(APD-371 | Olorinab)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at recombinant human CB1 receptor expressed in HEK293 cells assessed as increase in beta arrestin recruitment measured after 2 to 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50285941(APD-371 | Olorinab)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2020
Entry Details Article
PubMed