BDBM14146 APC-9008::{amino[2-(3,5-dichloro-2-hydroxyphenyl)-1H-indol-5-yl]methylidene}azanium

SMILES NC(=[NH2+])c1ccc2[nH]c(cc2c1)-c1cc(Cl)cc(Cl)c1O

InChI Key InChIKey=AACVRGGQVLDYDM-UHFFFAOYSA-O

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 14146   

TargetCoagulation factor X(Human)
Axys Pharmaceutical

LigandPNGBDBM14146({amino[2-(3,5-dichloro-2-hydroxyphenyl)-1H-indol-5...)
Affinity DataKi:  70nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceutical

LigandPNGBDBM14146({amino[2-(3,5-dichloro-2-hydroxyphenyl)-1H-indol-5...)
Affinity DataKi:  200nM ΔG°:  -9.04kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed
TargetProthrombin(Human)
Axys Pharmaceutical

LigandPNGBDBM14146({amino[2-(3,5-dichloro-2-hydroxyphenyl)-1H-indol-5...)
Affinity DataKi:  210nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Axys Pharmaceutical

LigandPNGBDBM14146({amino[2-(3,5-dichloro-2-hydroxyphenyl)-1H-indol-5...)
Affinity DataKi:  350nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Axys Pharmaceutical

LigandPNGBDBM14146({amino[2-(3,5-dichloro-2-hydroxyphenyl)-1H-indol-5...)
Affinity DataKi:  850nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed
TargetPlasminogen(Human)
Axys Pharmaceutical

LigandPNGBDBM14146({amino[2-(3,5-dichloro-2-hydroxyphenyl)-1H-indol-5...)
Affinity DataKi:  1.50E+3nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed