BDBM50218528 3-(4-((benzyl(ethyl)amino)methyl)phenyl)-6,7-dimethoxy-2H-chromen-2-one::3-{4-[(benzylethylamino)methyl]phenyl}-6,7-dimethoxychromen-2-one::AP-2243::CHEMBL244416

SMILES CCN(Cc1ccccc1)Cc1ccc(cc1)-c1cc2cc(OC)c(OC)cc2oc1=O

InChI Key InChIKey=PNZIOQNBQOTGPK-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50218528   

TargetBeta-secretase 1(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50218528(AP-2243 | 3-{4-[(benzylethylamino)methyl]phenyl}-6...)
Affinity DataIC50: 238nMAssay Description:Inhibition of human recombinant BACE1 by spectrofluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50218528(AP-2243 | 3-{4-[(benzylethylamino)methyl]phenyl}-6...)
Affinity DataIC50: 18nMAssay Description:Inhibition of human recombinant AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50218528(AP-2243 | 3-{4-[(benzylethylamino)methyl]phenyl}-6...)
Affinity DataIC50: 1.18E+5nMAssay Description:Inhibition of human recombinant BChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50218528(AP-2243 | 3-{4-[(benzylethylamino)methyl]phenyl}-6...)
Affinity DataIC50: 18nMAssay Description:Inhibition of human recombinant AChE by Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50218528(AP-2243 | 3-{4-[(benzylethylamino)methyl]phenyl}-6...)
Affinity DataIC50: 18nMAssay Description:Inhibition of human acetylcholinesterase using acetylthiocholine iodide as substrate incubated for 20 mins prior to substrate addition by Ellmans met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50218528(AP-2243 | 3-{4-[(benzylethylamino)methyl]phenyl}-6...)
Affinity DataKi:  11nMAssay Description:Inhibition of recombinant human AChE assessed as hydrolysis of acetylthiocholine by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed