BDBM50319665 (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one::AMG-221::CHEMBL1085107

SMILES CC(C)[C@]1(C)SC(N[C@H]2C[C@@H]3CC[C@H]2C3)=NC1=O

InChI Key InChIKey=YCNCXQNUXCHRRX-UHFFFAOYSA-N

Data  3 KI  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50319665   

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50319665(AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...)
Affinity DataIC50: 3.66nMAssay Description:Inhibition of adipose tissue-derived 11beta-HSD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50319665(AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...)
Affinity DataIC50: 10.1nMAssay Description:Displacement of [3H]-cortisone human 17beta-HSD1 expressed in HEK293 cells after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319665(AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 11beta-HSD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50319665(AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 11beta-HSD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50319665(AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50319665(AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50319665(AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50319665(AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50319665(AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50319665(AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50319665(AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...)
Affinity DataIC50: 470nMAssay Description:Inhibition of 11beta-HSD1 in mouse liver microsomes using cortisone as substrate after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50319665(AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...)
Affinity DataIC50: 7nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using cortisone as substrate after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50319665(AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...)
Affinity DataIC50: 10.1nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50319665(AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...)
Affinity DataKi:  12.8nMAssay Description:Displacement of [3H]-cortisone human 17beta-HSD1 expressed in Escherichia coli after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50319665(AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...)
Affinity DataKi:  12.8nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50319665(AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...)
Affinity DataKi:  70.8nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed