BDBM50586360 ADR-529::CHEBI:50223::Cardioxane::DEXRAZOXANE::Dexrazoxane::ICRF-187::NSC-169780::Razoxane, (s)-::Razoxane, d-::Zinecard

SMILES C[C@@H](CN1CC(=O)NC(=O)C1)N1CC(=O)NC(=O)C1

InChI Key InChIKey=BMKDZUISNHGIBY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50586360   

TargetDNA topoisomerase 2-alpha(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50586360(DEXRAZOXANE | CHEBI:50223 | Dexrazoxane | Razoxane...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human TOP2A assessed as reduction in relaxation of supercoiled DNA using kDNA as substrate incubated for 30 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50586360(DEXRAZOXANE | CHEBI:50223 | Dexrazoxane | Razoxane...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human TOP2B assessed as reduction in relaxation of supercoiled DNA using kDNA as substrate incubated for 30 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed