BindingDB BDBM50094703 5-(3-Bromo-phenyl)-7-(6-morpholin-4-yl-pyridin-3-yl)-pyrido[2,3-d]pyrimidin-4-ylamine::5-(3-bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-ylamine::ABT-702::CHEMBL66089

BDBM50094703 5-(3-Bromo-phenyl)-7-(6-morpholin-4-yl-pyridin-3-yl)-pyrido[2,3-d]pyrimidin-4-ylamine::5-(3-bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-ylamine::ABT-702::CHEMBL66089

SMILES Nc1ncnc2nc(cc(-c3cccc(Br)c3)c12)-c1ccc(nc1)N1CCOCC1

InChI Key InChIKey=RQCXKDWOCUJWQZ-UHFFFAOYSA-N

Data 77 KI 11 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 88 hits for monomerid = 50094703

Adenosine kinase(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

IC50: 1.70nMAssay Description:Inhibition of human adenosine kinase assessed as reduction in conversion of adenosine to AMPMore data for this Ligand-Target Pair

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Date in BDB:
2/27/2021
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Adenosine kinase(Rat)
Abbott Laboratories

Curated by ChEMBL

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

IC50: 50nMAssay Description:Inhibitory activity against intact cell adenosine kinase by ADO phosphorylation assayMore data for this Ligand-Target Pair

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Date in BDB:
11/10/2009
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Adenosine kinase(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

IC50: 43nMAssay Description:In vitro concentration required for 50% inhibition against Adenosine Kinase (AK) in the presence of intact cellsMore data for this Ligand-Target Pair

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Date in BDB:
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Adenosine kinase(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

IC50: 1.70nMAssay Description:Inhibitory concentration against adenosine kinaseMore data for this Ligand-Target Pair

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Date in BDB:
11/30/2012
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Adenosine kinase(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

IC50: 2nMAssay Description:Inhibition of adenosine kinase (unknown origin)More data for this Ligand-Target Pair

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Date in BDB:
4/23/2016
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Adenosine kinase(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

IC50: 10nMAssay Description:Inhibitory activity against human adenosine kinase expressed in Escherichia coliMore data for this Ligand-Target Pair

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Date in BDB:
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Adenosine kinase(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

IC50: 50nMAssay Description:Inhibition of adenosine phosphorylation in confluent IMR-32 (human neuroblastoma) cells.More data for this Ligand-Target Pair

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Adenosine kinase(Rat)
Abbott Laboratories

Curated by ChEMBL

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

IC50: 1.70nMAssay Description:In vitro inhibition of Adenosine kinase (AK)More data for this Ligand-Target Pair

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Adenosine kinase(Rat)
Abbott Laboratories

Curated by ChEMBL

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

IC50: 2nMAssay Description:Inhibitory activity against cytosolic adenosine kinase by ADO phosphorylation assayMore data for this Ligand-Target Pair

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Adenosine kinase(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

IC50: 1.70nMAssay Description:Tested for inhibitory activity against AK in an in vitro cell-free enzyme assayMore data for this Ligand-Target Pair

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Adenosine kinase(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

IC50: 43.3nMAssay Description:In vitro concentration required for 50% inhibition against Adenosine Kinase (AK) in the presence of intact cellsMore data for this Ligand-Target Pair

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Date in BDB:
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Sodium-dependent dopamine transporter(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: 1.69E+3nMMore data for this Ligand-Target Pair

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Date in BDB:
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Muscarinic acetylcholine receptor M1(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: 2.71E+3nMMore data for this Ligand-Target Pair

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Date in BDB:
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Delta-type opioid receptor(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: 4.12E+3nMMore data for this Ligand-Target Pair

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Kappa-type opioid receptor(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: 4.60E+3nMMore data for this Ligand-Target Pair

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Substance-K receptor(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: 8.56E+3nMMore data for this Ligand-Target Pair

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Date in BDB:
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5-hydroxytryptamine receptor 2A(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Alpha-2C adrenergic receptor(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Alpha-1A adrenergic receptor(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 7(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 6(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 5A(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 3A(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2C(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1B(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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VIP peptides(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Vasopressin V2 receptor(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Vasopressin V1a receptor(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Thromboxane A2 receptor(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Tumor necrosis factor(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Somatostatin(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Sodium channel protein type 2 subunit alpha(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Gastrin/cholecystokinin type B receptor(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Voltage-dependent calcium channel gamma-1 subunit(Human)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Calcium release-activated calcium channel protein 1(Human)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1C(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Cannabinoid receptor 1(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Cannabinoid receptor 2(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Calcitonin gene-related peptide 1(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Chloride channel protein 1(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Gastrin/cholecystokinin type B receptor(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Sigma non-opioid intracellular receptor 1(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Muscarinic acetylcholine receptor M2(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Muscarinic acetylcholine receptor M3(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Gamma-aminobutyric acid receptor subunit alpha-1(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Gamma-aminobutyric acid receptor subunit alpha-1(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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B2 bradykinin receptor(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Sodium/potassium-transporting ATPase subunit alpha-1(Rat)
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Displayed 1 to 50 (of 88 total ) | Next | Last >>

Filter my 88 hits

Targets 76▿
- Adenosine kinase 11
- Gastrin/cholecystokinin type B receptor 2
- Gamma-aminobutyric acid receptor subunit alpha-1 2
- Voltage-dependent calcium channel gamma-1 subunit 1
- Type-2 angiotensin II receptor 1
- Endothelin-1 receptor 1
- Galanin peptides 1
- Interleukin-1 alpha 1
- Muscarinic acetylcholine receptor M5 1
- Muscarinic acetylcholine receptor M4 1
- 5'-nucleotidase 1
- Muscarinic acetylcholine receptor M3 1
- Muscarinic acetylcholine receptor M2 1
- Muscarinic acetylcholine receptor M1 1
- Calcium release-activated calcium channel protein 1 1
- Beta-2 adrenergic receptor 1
- Platelet-derived growth factor subunit A 1
- D(4) dopamine receptor 1
- Beta-1 adrenergic receptor 1
- Calcitonin gene-related peptide 1 1
- D(2) dopamine receptor 1
- Delta-type opioid receptor 1
- 5-hydroxytryptamine receptor 3A 1
- Prostaglandin G/H synthase 2 1
- Prostaglandin G/H synthase 1 1
- Bombesin receptor subtype-3 1
- Alpha-1A adrenergic receptor 1
- Neuronal acetylcholine receptor subunit alpha-4 1
- Norepinephrine transporter 1
- Sodium-dependent dopamine transporter 1
- B2 bradykinin receptor 1
- Glutamate receptor 3 1
- Alpha-2C adrenergic receptor 1
- Potassium voltage-gated channel subfamily H member 8 1
- Gamma-aminobutyric acid (GABA) B receptor 1 1
- Tumor necrosis factor 1
- Type-1 angiotensin II receptor A 1
- ATP-sensitive inward rectifier potassium channel 1 1
- 5-hydroxytryptamine receptor 2C 1
- D(1B) dopamine receptor 1
- 5-hydroxytryptamine receptor 2A 1
- D(1A) dopamine receptor 1
- 5-hydroxytryptamine receptor 7 1
- 5-hydroxytryptamine receptor 6 1
- Sodium channel protein type 1 subunit alpha 1
- Vasopressin V1a receptor 1
- Sodium channel protein type 2 subunit alpha 1
- Sigma non-opioid intracellular receptor 1 1
- Glutamate receptor ionotropic, NMDA 1 1
- Prostacyclin receptor 1
- Melatonin receptor type 1A 1
- Substance-K receptor 1
- D(3) dopamine receptor 1
- Kappa-type opioid receptor 1
- Vasopressin V2 receptor 1
- Histamine H1 receptor 1
- 5-hydroxytryptamine receptor 1B 1
- Sodium/potassium-transporting ATPase subunit alpha-1 1
- Somatostatin 1
- Chloride channel protein 1 1
- Pro-neuropeptide Y 1
- Voltage-dependent L-type calcium channel subunit alpha-1C 1
- Mu-type opioid receptor 1
- Thromboxane A2 receptor 1
- Amine oxidase [flavin-containing] B 1
- 5-hydroxytryptamine receptor 5A 1
- Substance-P receptor 1
- Neuropeptide Y receptor type 2 1
- Neuromedin-K receptor 1
- Glutamate receptor ionotropic, kainate 1 1
- Cannabinoid receptor 1 1
- VIP peptides 1
- Calcium-activated potassium channel subunit beta-1 1
- Endothelin receptor type B 1
- Cannabinoid receptor 2 1
- Histamine H2 receptor 1
Publications 9▿
- J Pharmacol Exp Ther 295: 1156-64 (2000) 77
- J Med Chem 44: 2133-8 (2001) 2
- Bioorg Med Chem Lett 11: 83-6 (2001) 2
- Bioorg Med Chem Lett 11: 2071-4 (2001) 2
- J Med Chem 43: 4781-6 (2000) 1
- J Med Chem 47: 3463-82 (2004) 1
- Eur J Med Chem 95: 76-95 (2015) 1
- Bioorg Med Chem Lett 14: 1997-2000 (2004) 1
- J Med Chem 59: 6860-77 (2016) 1
Institutions 5▿
- Abbott Laboratories 84
- National Institute of Diabetes and Digestive and Kidney Diseases 1
- Bayer 1
- Sunesis Pharmaceuticals 1
- Orleans University 1
Affinity: 1.7 to 1.0E+4 nM▿
- Ki 77
- IC50 11
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1