BDBM50573891 A-1282576::A-1282576.0::A-12825760::ABT-493::Glecaprevir

SMILES CC1(CC1)S(=O)(=O)NC(=O)[C@]2(C[C@H]2C(F)F)NC(=O)[C@@H]3C[C@@H]4CN3C(=O)[C@@H](NC(=O)O[C@@H]5CCC[C@H]5OC/C=C/C(c6c(nc7ccccc7n6)O4)(F)F)C(C)(C)C

InChI Key InChIKey=MLSQGNCUYAMAHD-UHFFFAOYSA-N

Data  2 KI

PDB links: 10 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50573891   

TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
University of Massachusetts Medical School

Curated by ChEMBL
LigandPNGBDBM50573891(Glecaprevir | A-1282576 | A-1282576.0 | A-12825760...)
Affinity DataKi:  0.0500nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
University of Massachusetts Medical School

Curated by ChEMBL
LigandPNGBDBM50573891(Glecaprevir | A-1282576 | A-1282576.0 | A-12825760...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of HCV GT-3a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)