BDBM50453112 ABT-267::CHEBI:85183::Ombitasvir
SMILES COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)Nc1ccc(cc1)[C@@H]1CC[C@H](N1c1ccc(cc1)C(C)(C)C)c1ccc(NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)OC)C(C)C)cc1
InChI Key InChIKey=PIDFDZJZLOTZTM-UHFFFAOYSA-N
Data 18 EC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 18 hits for monomerid = 50453112
Affinity DataEC50: 0.366nMAssay Description:Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 6a assessed as decrease in viral replication after 3 days by luc...More data for this Ligand-Target Pair
TargetNonstructural protein 5A(Hepacivirus C)
Chia Tai Tianqing Pharmaceutical Group
Curated by ChEMBL
Chia Tai Tianqing Pharmaceutical Group
Curated by ChEMBL
Affinity DataEC50: 0.00500nMAssay Description:Inhibition of NS5A in HCV genotype 1b infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase rep...More data for this Ligand-Target Pair
TargetNonstructural protein 5A(Hepacivirus C)
Chia Tai Tianqing Pharmaceutical Group
Curated by ChEMBL
Chia Tai Tianqing Pharmaceutical Group
Curated by ChEMBL
Affinity DataEC50: 0.0550nMAssay Description:Inhibition of NS5A in HCV genotype 6aMore data for this Ligand-Target Pair
TargetNonstructural protein 5A(Hepacivirus C)
Chia Tai Tianqing Pharmaceutical Group
Curated by ChEMBL
Chia Tai Tianqing Pharmaceutical Group
Curated by ChEMBL
Affinity DataEC50: 0.00400nMAssay Description:Inhibition of NS5A in HCV genotype 5a infected in human HuH7 replicon cells expressing HCV genotype 1b chimeric replicon assessed as reduction in vir...More data for this Ligand-Target Pair
TargetNonstructural protein 5A(Hepacivirus C)
Chia Tai Tianqing Pharmaceutical Group
Curated by ChEMBL
Chia Tai Tianqing Pharmaceutical Group
Curated by ChEMBL
Affinity DataEC50: 0.000300nMAssay Description:Inhibition of NS5A in HCV genotype 4a infected in human HuH7 replicon cells expressing HCV genotype 1b chimeric replicon assessed as reduction in vir...More data for this Ligand-Target Pair
Affinity DataEC50: 0.00260nMAssay Description:Inhibition of NS5A in HCV genotype 2a JFH-1 infected in human Huh7.5.1 cells assessed as reduction in viral replication after 3 days by luciferase re...More data for this Ligand-Target Pair
TargetNonstructural protein 5A(Hepacivirus C)
Chia Tai Tianqing Pharmaceutical Group
Curated by ChEMBL
Chia Tai Tianqing Pharmaceutical Group
Curated by ChEMBL
Affinity DataEC50: 0.0300nMAssay Description:Inhibition of NS5A in HCV genotype 1a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase rep...More data for this Ligand-Target Pair
TargetNonstructural protein 5A(Hepacivirus C)
Chia Tai Tianqing Pharmaceutical Group
Curated by ChEMBL
Chia Tai Tianqing Pharmaceutical Group
Curated by ChEMBL
Affinity DataEC50: 3.39nMAssay Description:Inhibition of NS5A in HCV genotype 6a infected in human HuH7 replicon cells expressing HCV genotype 1b chimeric replicon assessed as reduction in vir...More data for this Ligand-Target Pair
TargetNonstructural protein 5A(Hepacivirus C)
Chia Tai Tianqing Pharmaceutical Group
Curated by ChEMBL
Chia Tai Tianqing Pharmaceutical Group
Curated by ChEMBL
Affinity DataEC50: 0.0860nMAssay Description:Inhibition of NS5A in HCV genotype 3a infected in human HuH7 replicon cells expressing HCV genotype 1b chimeric replicon assessed as reduction in vir...More data for this Ligand-Target Pair
Affinity DataEC50: 0.00430nMAssay Description:Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 2b assessed as decrease in viral replication after 3 days by luc...More data for this Ligand-Target Pair
TargetNonstructural protein 5A(Hepacivirus C)
Chia Tai Tianqing Pharmaceutical Group
Curated by ChEMBL
Chia Tai Tianqing Pharmaceutical Group
Curated by ChEMBL
Affinity DataEC50: 0.186nMAssay Description:Inhibition of NS5A in HuH7 cell infected HCV genotype 1a H77 assessed as decrease in viral replication after 3 days in presence of 40% human plasma b...More data for this Ligand-Target Pair
TargetNonstructural protein 5A(Hepacivirus C)
Chia Tai Tianqing Pharmaceutical Group
Curated by ChEMBL
Chia Tai Tianqing Pharmaceutical Group
Curated by ChEMBL
Affinity DataEC50: 0.0140nMAssay Description:Inhibition of NS5A in HuH7 cell infected HCV genotype 1a H77 assessed as decrease in viral replication after 3 days by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.00170nMAssay Description:Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 4a assessed as decrease in viral replication after 3 days by luc...More data for this Ligand-Target Pair
Affinity DataEC50: 0.00320nMAssay Description:Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 5a assessed as decrease in viral replication after 3 days by luc...More data for this Ligand-Target Pair
Affinity DataEC50: 0.00500nMAssay Description:Inhibition of NS5A in HuH7 cell infected HCV genotype 1b Con1 assessed as decrease in viral replication after 3 days by luciferase reporter gene assa...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0190nMAssay Description:Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 3a assessed as decrease in viral replication after 3 days by luc...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0560nMAssay Description:Inhibition of NS5A in HuH7 cell infected HCV genotype 1b Con1 assessed as decrease in viral replication after 3 days in presence of 40% human plasma ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0120nMAssay Description:Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 2a assessed as decrease in viral replication after 3 days by luc...More data for this Ligand-Target Pair