BDBM13389 4-{[(4-cyanophenyl)methoxy](1-methyl-1H-imidazol-5-yl)methyl}-2-(naphthalen-1-yl)benzonitrile::A313326::CHEMBL41748

SMILES Cn1cncc1C(OCc1ccc(cc1)C#N)c1ccc(C#N)c(c1)-c1cccc2ccccc12

InChI Key InChIKey=ZBRVJLSHNVWEKS-UHFFFAOYSA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 13389   

TargetProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha(Human)
Globe Pharmaceutical R and Abbott Laboratories

LigandPNGBDBM13389(CHEMBL41748 | 4-{[(4-cyanophenyl)methoxy](1-methyl...)
Affinity DataIC50: 0.300nMpH: 7.0 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetGeranylgeranyl transferase type-1 subunit beta(Bovine)
Globe Pharmaceutical R and Abbott Laboratories

LigandPNGBDBM13389(CHEMBL41748 | 4-{[(4-cyanophenyl)methoxy](1-methyl...)
Affinity DataIC50: 18nMAssay Description:The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
LigandPNGBDBM13389(CHEMBL41748 | 4-{[(4-cyanophenyl)methoxy](1-methyl...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of Bovine farnesyl transferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM13389(CHEMBL41748 | 4-{[(4-cyanophenyl)methoxy](1-methyl...)
Affinity DataIC50: 18nMAssay Description:Inhibition of Bovine geranylgeranyl transferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM13389(CHEMBL41748 | 4-{[(4-cyanophenyl)methoxy](1-methyl...)
Affinity DataEC50:  110nMAssay Description:Effective concentration against H-ras processing in transformed NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM13389(CHEMBL41748 | 4-{[(4-cyanophenyl)methoxy](1-methyl...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of [3H]FPP transfer to biotin K-ras peptide (KKSKTKCVIM) by bovine FTaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM13389(CHEMBL41748 | 4-{[(4-cyanophenyl)methoxy](1-methyl...)
Affinity DataIC50: 18nMAssay Description:Inhibition of [3H]FPP transfer to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine GGTase-IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed