BDBM50033114 (5aR,11bS)-2-Propyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-aza-cyclopenta[c]phenanthrene-9,10-diol::2-Propyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-aza-cyclopenta[c]phenanthrene-9,10-diol::A-86929::CHEMBL28338

SMILES CCCc1cc2[C@H]3[C@@H](CCc4cc(O)c(O)cc34)NCc2s1

InChI Key InChIKey=REHAKLRYABHSQJ-UHFFFAOYSA-N

Data  6 KI  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50033114   

TargetD(1A) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50033114(2-Propyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-aza-cyc...)
Affinity DataEC50:  9nMAssay Description:Potency in adenylate cyclase functional assay against Dopamine receptor D1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50033114(2-Propyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-aza-cyc...)
Affinity DataEC50:  3.90E+3nMAssay Description:Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50033114(2-Propyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-aza-cyc...)
Affinity DataEC50:  9nMAssay Description:Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetD(1) dopamine receptor(Goldfish)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50033114(2-Propyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-aza-cyc...)
Affinity DataEC50:  24nMAssay Description:Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50033114(2-Propyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-aza-cyc...)
Affinity DataKi:  14nMAssay Description:In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50033114(2-Propyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-aza-cyc...)
Affinity DataKi:  49nMAssay Description:Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50033114(2-Propyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-aza-cyc...)
Affinity DataKi:  49nMAssay Description:Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50033114(2-Propyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-aza-cyc...)
Affinity DataKi:  710nMAssay Description:Binding affinity to human Dopamine receptor D2 by using radioligand [3H]spiperone in LTK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50033114(2-Propyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-aza-cyc...)
Affinity DataKi:  710nMAssay Description:Binding affinity against cloned human Dopamine receptor D2 using [3H]spiperone as radioligand transfected in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50033114(2-Propyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-aza-cyc...)
Affinity DataKi:  800nMAssay Description:In vitro binding affinity against Dopamine receptor D2 like from rat caudate membrane using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMed