BDBM50007534 3-Bromo-N-((S)-1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide::3-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide::A 35043::CHEMBL283099

SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)c(Br)ccc1OC

InChI Key InChIKey=PWEZBNRZEHPIIQ-UHFFFAOYSA-N

Data  13 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50007534   

TargetD(2) dopamine receptor(Rat)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50007534(3-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydrox...)
Affinity DataIC50: 12nMAssay Description:Tested in vitro for inhibition of [3H]spiperone binding to dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50007534(3-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydrox...)
Affinity DataIC50: 21nMAssay Description:In vivo inhibitory activity against dopamine (D2) receptor in rat caudate-putamen tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50007534(3-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydrox...)
Affinity DataIC50: 12nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal dopamine receptor D2 was determined in vitroMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50007534(3-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydrox...)
Affinity DataIC50: 21nMAssay Description:In vitro binding affinity at Dopamine receptor D2 in rat by displacing [3H]- spiperone from rat striatal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50007534(3-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydrox...)
Affinity DataIC50: 12nMAssay Description:In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50007534(3-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydrox...)
Affinity DataIC50: 21nMAssay Description:In vitro binding affinity at Dopamine receptor D2 in rat by displacing [3H]- spiperone from rat striatal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50007534(3-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydrox...)
Affinity DataIC50: 12nMAssay Description:The affinity for the Dopamine receptor D2 was assessed by the inhibition of [3H]-spiperone binding in rat striatal membranes in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Mazandaran

Curated by ChEMBL
LigandPNGBDBM50007534(3-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydrox...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at dopamine D2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50007534(3-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydrox...)
Affinity DataKi:  0.550nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50007534(3-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydrox...)
Affinity DataKi:  0.550nMAssay Description:Inhibition of [3H]raclopride binding to rat striatal dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50007534(3-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydrox...)
Affinity DataKi:  6.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50007534(3-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydrox...)
In Depth
Date in BDB:
11/23/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50007534(3-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydrox...)
Affinity DataKi:  10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Astra LÄKemedel

Curated by PDSP Ki Database
LigandPNGBDBM50007534(3-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydrox...)
Affinity DataKi:  1.02E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
Astra LÄKemedel

Curated by PDSP Ki Database
LigandPNGBDBM50007534(3-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydrox...)
Affinity DataKi:  1.05E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
Astra LÄKemedel

Curated by PDSP Ki Database
LigandPNGBDBM50007534(3-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydrox...)
Affinity DataKi:  3.22E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Astra LÄKemedel

Curated by PDSP Ki Database
LigandPNGBDBM50007534(3-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydrox...)
Affinity DataKi:  5.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
Astra LÄKemedel

Curated by PDSP Ki Database
LigandPNGBDBM50007534(3-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydrox...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
Astra LÄKemedel

Curated by PDSP Ki Database
LigandPNGBDBM50007534(3-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydrox...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Astra LÄKemedel

Curated by PDSP Ki Database
LigandPNGBDBM50007534(3-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydrox...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Rat)
Astra LÄKemedel

Curated by PDSP Ki Database
LigandPNGBDBM50007534(3-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydrox...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details Article
PubMed