BDBM50028124 2-(6-Methoxy-1H-indol-3-yl)-ethylamine::2-(6-methoxy-1H-indol-3-yl)ethanamine::6-MeOT::CHEMBL337825

SMILES COc1ccc2c(c1)[nH]cc2CCN

InChI Key InChIKey=VOCGEKMEZOPDFP-UHFFFAOYSA-N

Data  2 KI  2 IC50  4 EC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50028124   

TargetSodium-dependent serotonin transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50028124(CHEMBL337825 | 6-MeOT | 2-(6-methoxy-1H-indol-3-yl...)
Affinity DataEC50:  54nMAssay Description:Induction of 5-HTT-mediated 5-HT release in rat brain synaptosomes by [3H]5-HT release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details Article
PubMed
TargetTransporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50028124(CHEMBL337825 | 6-MeOT | 2-(6-methoxy-1H-indol-3-yl...)
Affinity DataEC50:  465nMAssay Description:Induction of NET-mediated norepinephrine release in rat brain synaptosomes by [3H]NE release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50028124(CHEMBL337825 | 6-MeOT | 2-(6-methoxy-1H-indol-3-yl...)
Affinity DataEC50:  113nMAssay Description:Induction of DAT-mediated dopamine release in rat brain synaptosomes by [3H]DA release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50028124(CHEMBL337825 | 6-MeOT | 2-(6-methoxy-1H-indol-3-yl...)
Affinity DataEC50:  2.44E+3nMAssay Description:Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details Article
PubMed
LigandPNGBDBM50028124(CHEMBL337825 | 6-MeOT | 2-(6-methoxy-1H-indol-3-yl...)
Affinity DataIC50: 630nMAssay Description:Evaluated for inhibition of specific [3H]5-HT receptor binding in rat cortex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily B member 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50028124(CHEMBL337825 | 6-MeOT | 2-(6-methoxy-1H-indol-3-yl...)
Affinity DataIC50: 5.24E+5nMAssay Description:Inhibition of voltage-gated potassium channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Guinea pig)
Syntex Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM50028124(CHEMBL337825 | 6-MeOT | 2-(6-methoxy-1H-indol-3-yl...)
Affinity DataKi:  36.3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Guinea pig)
Syntex Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM50028124(CHEMBL337825 | 6-MeOT | 2-(6-methoxy-1H-indol-3-yl...)
Affinity DataKi:  363nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2011
Entry Details Article
PubMed