BDBM50203188 2-((1r,4r)-4-(4-chlorophenyl)cyclohexyl)-3-hydroxynaphthalene-1,4-dione::2-[4-(4-Chloro-phenyl)-cyclohexyl]-3-hydroxy-[1,4]naphthoquinone::2-[4-(4-Chloro-phenyl)-cyclohexyl]-3-hydroxy-[1,4]naphthoquinone(atovaquone)::3-(4-(4-chlorophenyl)cyclohexyl)-4-hydroxynaphthalene-1,2-dione::566C::566C80::ATOVAQUONE::CHEMBL1450::Mepron::trans-3-(4-(4-chlorophenyl)cyclohexyl)-1,4-dihydronaphthalene-1,2,4-triol

SMILES Clc1ccc(cc1)[C@H]1CC[C@@H](CC1)C1C(=O)C(=O)c2ccccc2C1=O

InChI Key InChIKey=UYFLKEIEOREOFC-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50203188   

LigandPNGBDBM50203188(CHEMBL1450 | 2-((1r,4r)-4-(4-chlorophenyl)cyclohex...)
Affinity DataIC50: 700nMAssay Description:Inhibition of rat purified recombinant DHODHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Institut Pasteur

Curated by ChEMBL
LigandPNGBDBM50203188(CHEMBL1450 | 2-((1r,4r)-4-(4-chlorophenyl)cyclohex...)
Affinity DataIC50: 1.45E+4nMAssay Description:Inhibition of human purified recombinant DHODHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(malaria parasite P. falciparum)
Harvard School of Public Health

Curated by ChEMBL
LigandPNGBDBM50203188(CHEMBL1450 | 2-((1r,4r)-4-(4-chlorophenyl)cyclohex...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Plasmodium falciparum DHODMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (fumarate)(Baker's yeast)
Harvard School of Public Health

Curated by ChEMBL
LigandPNGBDBM50203188(CHEMBL1450 | 2-((1r,4r)-4-(4-chlorophenyl)cyclohex...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Saccharomyces cerevisiae DHODMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Blood fluke)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50203188(CHEMBL1450 | 2-((1r,4r)-4-(4-chlorophenyl)cyclohex...)
Affinity DataIC50: 432nMAssay Description:Inhibition of Schistosoma mansoni DHODH using DHO as substrate measured at 4 secs interval for 60 secs by DCIP reduction based indirect assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Institut Pasteur

Curated by ChEMBL
LigandPNGBDBM50203188(CHEMBL1450 | 2-((1r,4r)-4-(4-chlorophenyl)cyclohex...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of human DHODH using DHO as substrate measured at 4 secs interval for 60 secs by DCIP reduction based indirect assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Blood fluke)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50203188(CHEMBL1450 | 2-((1r,4r)-4-(4-chlorophenyl)cyclohex...)
Affinity DataIC50: 430nMAssay Description:Inhibition of Schistosoma mansoni DHODHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Institut Pasteur

Curated by ChEMBL
LigandPNGBDBM50203188(CHEMBL1450 | 2-((1r,4r)-4-(4-chlorophenyl)cyclohex...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human DHODHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Institut Pasteur

Curated by ChEMBL
LigandPNGBDBM50203188(CHEMBL1450 | 2-((1r,4r)-4-(4-chlorophenyl)cyclohex...)
Affinity DataIC50: 1.45E+4nMAssay Description:Inhibition of recombinant human DHODH expressed in baculovirus infected insect cells using dihydroorotate as substrate and decylubiquinone as co-subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Federal University of Parana

Curated by ChEMBL
LigandPNGBDBM50203188(CHEMBL1450 | 2-((1r,4r)-4-(4-chlorophenyl)cyclohex...)
Affinity DataIC50: 230nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in human HEK293 cells membrane vesicles assessed inhibition of BCRP- mediated transport of 3[H]-E1S fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed