BDBM50030628 (S)-4C3HPG::4-(Amino-carboxy-methyl)-2-hydroxy-benzoic acid::4-(Amino-carboxy-methyl)-2-hydroxy-benzoic acid(S-4C3HPG)::4C3HPG::CHEMBL444589

SMILES NC(C(O)=O)c1ccc(C(O)=O)c(O)c1

InChI Key InChIKey=GXZSAQLJWLCLOX-UHFFFAOYSA-N

Data  10 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50030628   

TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50030628(CHEMBL444589 | 4-(Amino-carboxy-methyl)-2-hydroxy-...)
Affinity DataIC50: 2.00E+5nMAssay Description:Compound was tested for inhibition of glutamate-evoked (10 uM) [Ca2+] mobilization in mGluR1-alpha expressed-CHO cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50030628(CHEMBL444589 | 4-(Amino-carboxy-methyl)-2-hydroxy-...)
Affinity DataIC50: 4.00E+4nMAssay Description:Ability to inhibit mGluR1-alpha-mediated PI (phospho inositol) hydrolysis was determined at BHK cells at 100 Micro M ConcentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50030628(CHEMBL444589 | 4-(Amino-carboxy-methyl)-2-hydroxy-...)
Affinity DataIC50: 4.80E+4nMAssay Description:Ability to inhibit mGluR2-alpha induced cAMP formation was determined at BHK cells at 100 Micro M ConcentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50030628(CHEMBL444589 | 4-(Amino-carboxy-methyl)-2-hydroxy-...)
Affinity DataIC50: 1.00E+6nMAssay Description:Ability to inhibit mGluR4-alpha induced cAMP formation was determined at BHK cells at 100 Micro M ConcentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandPNGBDBM50030628(CHEMBL444589 | 4-(Amino-carboxy-methyl)-2-hydroxy-...)
Affinity DataKi:  1.65nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50030628(CHEMBL444589 | 4-(Amino-carboxy-methyl)-2-hydroxy-...)
Affinity DataKi:  2.50E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50030628(CHEMBL444589 | 4-(Amino-carboxy-methyl)-2-hydroxy-...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50030628(CHEMBL444589 | 4-(Amino-carboxy-methyl)-2-hydroxy-...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50030628(CHEMBL444589 | 4-(Amino-carboxy-methyl)-2-hydroxy-...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50030628(CHEMBL444589 | 4-(Amino-carboxy-methyl)-2-hydroxy-...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandPNGBDBM50030628(CHEMBL444589 | 4-(Amino-carboxy-methyl)-2-hydroxy-...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50030628(CHEMBL444589 | 4-(Amino-carboxy-methyl)-2-hydroxy-...)
Affinity DataKi:  2.00E+4nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 2 (mGluR-2).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50030628(CHEMBL444589 | 4-(Amino-carboxy-methyl)-2-hydroxy-...)
Affinity DataKi:  3.00E+4nMAssay Description:Agonist potency against cloned human metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50030628(CHEMBL444589 | 4-(Amino-carboxy-methyl)-2-hydroxy-...)
Affinity DataKi: >1.00E+6nMAssay Description:Agonist potency against cloned human Metabotropic glutamate receptor 4 (mGluR-4)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed