BDBM707354 41-065::N-(3-(2-(dimethylamino)ethoxy)phenyl)-2-(6-fluoro-1H-indol-3-yl)acetamide::US20240408064, Compound 10095

SMILES CN(C)CCOc1cccc(NC(=O)Cc2c[nH]c3cc(F)ccc23)c1

InChI Key InChIKey=TYZBFOXAUNCTPS-UHFFFAOYSA-N

Data  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 707354   

TargetGTPase HRas [G12V,1-166]/Son of sevenless homolog 1 [564-1049](Homo sapiens (Human))
Genetolead

US Patent
LigandPNGBDBM707354(N-(3-(2-(dimethylamino)ethoxy)phenyl)-2-(6-fluoro-...)
Affinity DataKd:  36nMAssay Description:Dissociation constants were obtained by monitoring changes in chemical shifts as a function of ligand concentration. The changes in chemical shifts (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetGTPase HRas [G12V,1-166]/Son of sevenless homolog 1 [564-1049](Homo sapiens (Human))
Genetolead

US Patent
LigandPNGBDBM707354(N-(3-(2-(dimethylamino)ethoxy)phenyl)-2-(6-fluoro-...)
Affinity DataKd:  2.13E+4nMAssay Description:MST experiments were performed with a Monolith NT.115 Pico (NanoTemper Technologies, Munich, Germany). Fluorescence labeling of GDP-HRasG12V was achi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent